Opportunity Information: Apply for W81XWH 21 OCRP PA

The CDMRP Ovarian Cancer Research Program (OCRP) Pilot Award is a Department of Defense funding opportunity designed to help researchers test bold, new ideas in ovarian cancer that could open up fresh directions for the field. The core purpose is to support early-stage, innovative concepts or theories that have the potential to lead to major discoveries or meaningful advances in how ovarian cancer is understood, prevented, detected, or treated. Rather than rewarding incremental work, this mechanism is meant to push research that can challenge, expand, or reshape current scientific thinking and approaches related to ovarian cancer.

Projects submitted to this Pilot Award must have a clear and direct focus on ovarian cancer. Applicants are expected to ground their studies in ovarian cancer-relevant materials and systems, such as patient tissues, ovarian cancer cell lines, existing datasets, or well-justified animal models. If an application proposes using specific cell lines or animal models, the program expects a clear rationale for why those models are appropriate for the question being asked, reinforcing that model choice should be intentional and scientifically defensible rather than convenient or routine.

A key feature of the Pilot Award is its emphasis on generating a strong launching point for future, larger studies. Preliminary data are not required, which lowers the barrier for truly exploratory work and encourages risk-taking where the idea is compelling but early evidence may not yet exist. At the same time, preliminary data are allowed if the research team has them. Even without required pilot results, the proposed research still needs to be built around a well-formed, testable hypothesis supported by a strong scientific rationale, so the program is not looking for vague brainstorming but for rigorous, hypothesis-driven exploration.

Innovation is central to the intent of this award. The announcement makes clear that even projects with high scientific quality can miss the mark if they do not bring a genuinely innovative angle. In other words, strong methods alone are not enough; the application needs to demonstrate how it introduces a new concept, theory, or approach that could change the trajectory of ovarian cancer research. The expected outcome is the production of robust preliminary data that can serve as a credible foundation for follow-on funding and more extensive research efforts.

This opportunity does not support clinical trials, so proposals must stay on the preclinical, translational (non-trial), computational, or other non-clinical-trial research spectrum. Administratively, the opportunity is listed as a discretionary program within the Science and Technology and other Research and Development category (CFDA 12.420). The funding instrument type allows for either grants or cooperative agreements. Eligibility is described as unrestricted, meaning it is broadly open to many entity types as long as any additional eligibility conditions in the full announcement are met. The sponsor is the Department of Defense, Department of the Army, administered through USAMRAA. The opportunity (W81XWH 21 OCRP PA) was created on February 8, 2021, with an original closing date of July 8, 2021, and anticipated making about 10 awards. The award ceiling is listed as 0 in the provided source data, which typically indicates that the ceiling was not specified in that particular data field and would need to be confirmed in the full funding announcement or associated program guidance.

  • The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "CDMRP Ovarian Cancer Pilot Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on Feb 08, 2021.
  • Applicants must submit their applications by Jul 08, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 10 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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