Opportunity Information: Apply for W81XWH 19 CPMRP TRA
The DoD Chronic Pain Management Research Program (CPMRP) Translational Research Award (TRA) is a U.S. Department of Defense funding opportunity focused on moving solid, evidence-based chronic pain management findings closer to real-world use in clinical settings. The central goal is translation: taking what is already supported by credible research and accelerating its progression into practical clinical applications. That could include healthcare products, enabling technologies, or improvements that feed directly into clinical practice guidelines and standards of care. In other words, the program is not primarily looking for early-stage discovery work; it is looking for projects that help bridge the gap between existing evidence and routine care.
A key expectation for applications under this award is a clear explanation of how the proposed research will influence clinical practice. Proposals are expected to show a direct line from the planned work to the development, refinement, and/or revision of current standards of care, recommendations, or guidelines for managing chronic pain. Reviewers are likely looking for a well-argued path to impact: what clinical decision points or care pathways will change, what evidence will be generated to justify those changes, and how the work will support guideline developers, health systems, and clinicians in adopting improved approaches to chronic pain management.
At the same time, the opportunity places firm boundaries on what it will not support. Projects that aim to develop entirely new pharmacological therapies, or new non-pharmacological approaches, are not a fit if the effort is composed solely of a clinical trial. The mechanism is designed for translational work that may include clinical evaluation, but not proposals that are essentially "just a clinical trial" for a new intervention without the broader translational elements tied to implementation, practice standards, or guideline-relevant outcomes. In addition, clinical trials that evaluate opioid-based therapeutic interventions are explicitly prohibited, reflecting the program's constraints around opioid-focused treatment development and testing.
From an administrative standpoint, the opportunity is listed as a discretionary funding program under the Department of Defense, Department of the Army, administered through USAMRAA. The funding instrument types include both grants and cooperative agreements, indicating that some awards may involve more substantial agency involvement and coordination than a traditional standalone grant. The activity category is science and technology and other research and development, and the associated CFDA number is 12.420. Eligibility is described as unrestricted, meaning the competition is broadly open to many entity types, subject to any additional clarifications that may appear in the full announcement.
The original posting date for this specific opportunity was July 31, 2019, with an original closing date of December 6, 2019. The listing anticipated making about two awards. The stated award ceiling is shown as 0 in the provided source data, which typically means the ceiling was either not specified in that dataset extract or was to be defined elsewhere in the full funding announcement rather than implying no funding.
Overall, this Translational Research Award is best understood as a targeted mechanism for advancing evidence-based chronic pain management approaches into the kinds of outputs that change practice: clinically actionable products or tools, healthcare technologies that can be adopted in care delivery, and research findings packaged in a way that can directly support updates to guidelines and standards of care. The most competitive projects under this intent are those that do more than test an intervention; they generate the specific forms of evidence and implementation-relevant insight that help health systems and guideline bodies confidently improve how chronic pain is managed, while staying clear of opioid-intervention trials and avoiding a scope that is purely a standalone clinical trial for a novel therapy.Apply for W81XWH 19 CPMRP TRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Chronic Pain Management Research Program, Translational Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jul 31, 2019.
- Applicants must submit their applications by Dec 06, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD CPMRP Translational Research Award (TRA)
What is the DoD Chronic Pain Management Research Program (CPMRP) Translational Research Award (TRA)?
The CPMRP Translational Research Award (TRA) is a U.S. Department of Defense funding opportunity designed to move credible, evidence-based chronic pain management findings closer to real-world use in clinical settings. The emphasis is on translation: accelerating progress from established research evidence into practical clinical applications.
What is the central goal of this award?
The central goal is to bridge the gap between existing evidence and routine clinical care for chronic pain management. Projects are expected to help convert solid research findings into outputs that can be adopted in healthcare delivery and influence how clinicians manage chronic pain in practice.
What kinds of outcomes or deliverables does the TRA aim to support?
The program is oriented toward outputs that can change practice, such as healthcare products, enabling technologies, or improvements that feed directly into clinical practice guidelines and standards of care. The key expectation is that the work results in clinically actionable evidence or tools that support adoption in real-world settings.
Is this award intended for early-stage discovery or exploratory research?
No. The opportunity is not primarily aimed at early-stage discovery work. It focuses on projects that take findings already supported by credible research and move them toward practical clinical application.
How should an applicant explain clinical impact in a proposal?
Applications are expected to clearly explain how the proposed research will influence clinical practice. A competitive proposal should show a direct line from the planned work to the development, refinement, and/or revision of current standards of care, recommendations, or guidelines for chronic pain management.
What does it mean to show a "direct line" to standards of care or guidelines?
It means the proposal should articulate how the project will generate evidence that can support changes in clinical decision points or care pathways, and how that evidence can be used by guideline developers, health systems, and clinicians to adopt improved approaches to chronic pain management.
Does the TRA allow clinical evaluation as part of a project?
Yes, clinical evaluation may be included, but the program is not intended to fund proposals that are essentially only a clinical trial. The clinical components should be part of a broader translational plan tied to implementation, practice standards, or guideline-relevant outcomes.
Are proposals that are "just a clinical trial" considered responsive?
No. The mechanism is designed for translational work and does not fit proposals that consist solely of a clinical trial for a new intervention without broader translational elements linked to implementation and/or changes to practice standards and guidelines.
Can applicants propose development of entirely new pharmacological therapies under this award?
Projects aimed at developing entirely new pharmacological therapies are not a fit if the effort is composed solely of a clinical trial. The award is focused on translating existing evidence into practice, rather than supporting purely clinical-trial-only development of new therapies.
Can applicants propose development of entirely new non-pharmacological approaches under this award?
Similarly, projects aimed at developing entirely new non-pharmacological approaches are not a fit if the effort is composed solely of a clinical trial. The expectation is a broader translational pathway beyond a standalone trial.
Are opioid-based therapeutic intervention trials allowed?
No. Clinical trials that evaluate opioid-based therapeutic interventions are explicitly prohibited under this opportunity.
Which DoD components administer this opportunity?
The opportunity is listed under the Department of Defense, Department of the Army, and is administered through USAMRAA.
What types of funding instruments are used for awards under this opportunity?
The funding instrument types include grants and cooperative agreements. This indicates that some awards may involve more substantial agency involvement and coordination than a traditional standalone grant.
What is the activity category for this funding opportunity?
The activity category is listed as science and technology and other research and development.
What is the CFDA number associated with this opportunity?
The associated CFDA number is 12.420.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning the competition is broadly open to many entity types, subject to any additional clarifications that may appear in the full announcement.
When was this opportunity originally posted, and what was the closing date?
The original posting date was July 31, 2019, and the original closing date was December 6, 2019.
How many awards were anticipated?
The listing anticipated making about two awards.
What was the award ceiling for this opportunity?
The stated award ceiling is shown as 0 in the provided source data. This typically indicates that the ceiling was not specified in that dataset extract or was intended to be defined elsewhere in the full funding announcement, rather than implying that no funding was available.
What is the main theme reviewers are likely to look for in a strong application?
Reviewers are likely to look for a well-argued path to impact: how the project will translate established evidence into clinical practice, what practice changes could result, what guideline-relevant evidence will be generated, and how the work will support adoption by guideline bodies, health systems, and clinicians.
What is the simplest way to describe the "fit" for this award?
The best fit is a translational project that advances evidence-based chronic pain management approaches into real-world clinical use through actionable products, tools, technologies, or guideline-supporting evidence, while avoiding opioid-intervention trials and avoiding a scope that is purely a standalone clinical trial for a novel therapy.
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