Opportunity Information: Apply for PAR 18 101
The National Institutes of Health (NIH) is offering the Pilot and Feasibility Clinical Research Grants in Urologic Disorders (R21 Clinical Trial Optional) opportunity (Funding Opportunity Number PAR 18-101). This is a discretionary grant program that uses the NIH Exploratory/Developmental Research Grant mechanism (R21) to fund early-stage, small-scale clinical and translational studies focused on urologic disorders. The intent is to help investigators generate initial human-focused evidence, assess feasibility, refine protocols, and build the data needed to justify and design larger, full-scale clinical research projects.
This FOA specifically supports pilot and feasibility clinical and translational research, which can include epidemiological studies as well as clinical trials. Because the announcement is labeled "Clinical Trial Optional," applicants may propose either a study that is not a clinical trial (for example, a clinical observational study, a small translational study involving human participants, or an epidemiologic analysis) or an actual clinical trial, as long as it fits the exploratory and developmental nature of an R21. NIH is looking for projects that tackle important clinical and translational questions in urologic disorders and that have the potential for meaningful clinical and public health impact. In practical terms, the program is aimed at studies that are high-value but still at an early stage, where modest funding can clarify whether a concept is workable, safe, recruitable, and measurable, or whether a proposed diagnostic or therapeutic approach shows enough signal to justify a larger investment.
A key theme of the opportunity is that R21-funded projects are expected to serve as stepping stones. NIH anticipates that some of these awards will lead to larger, more definitive follow-on studies, such as full-scale epidemiological investigations, diagnostic strategy validation, or randomized clinical trials for prevention, diagnosis, or treatment of urologic disorders. In other words, the R21 here is positioned as a bridge between an idea with preliminary rationale and a later-stage, well-powered clinical study that can directly influence clinical practice or health policy.
From an eligibility standpoint, the FOA is broadly open to a wide range of applicant organizations. Eligible domestic applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and Native American tribal organizations other than federally recognized tribal governments. It also includes public housing authorities/Indian housing authorities, nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education), for-profit organizations (other than small businesses), and small businesses. The announcement also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and certain tribal governments that are not federally recognized. Notably, non-domestic (non-U.S.) entities (foreign organizations) are listed as eligible as well, which can be important for international collaborations or studies where relevant populations or expertise are located outside the United States.
The award information provided indicates an award ceiling of $200,000. The program is listed under Assistance Listing/CFDA number 93.847 and sits within the broad activity category of health (as displayed in the source data). The FOA record shows an original closing date of April 4, 2018, and a creation date of November 15, 2017, which signals that this particular posting reflects a specific historical application cycle; applicants interested in pursuing similar funding would typically look for a current reissue, renewal, or related NIH urologic disorders clinical research FOA using the same mechanism or program area.
Overall, this grant opportunity is designed for investigators and institutions that want to test a clinically relevant urologic disorders research idea in humans at a pilot scale, generate the kind of early evidence reviewers look for, and lay the groundwork for a larger, definitive clinical study that could ultimately improve prevention strategies, diagnostic approaches, or treatments in urologic health.Apply for PAR 18 101
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Pilot and Feasibility Clinical Research Grants in Urologic Disorders (R21 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2017-11-15.
- Applicants must submit their applications by 2018-04-04. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled Pilot and Feasibility Clinical Research Grants in Urologic Disorders (R21 Clinical Trial Optional).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR 18-101.
Which NIH grant mechanism does this program use?
This opportunity uses the NIH Exploratory/Developmental Research Grant (R21) mechanism, which is designed to support early-stage, exploratory, and development-focused projects.
What is the main purpose of this R21 program?
The purpose is to fund pilot and feasibility clinical and translational studies in urologic disorders so investigators can generate initial human-focused evidence, assess feasibility, refine protocols, and build the early data needed to justify and design larger, full-scale clinical research projects.
What types of studies does this FOA support?
The FOA supports pilot and feasibility clinical and translational research focused on urologic disorders. Examples described in the opportunity include epidemiological studies, clinical observational studies, and small translational studies involving human participants. It may also include clinical trials if appropriate for an exploratory/developmental R21.
Does the study have to be a clinical trial?
No. The FOA is labeled "Clinical Trial Optional", meaning applicants may propose either (1) a study that is not a clinical trial (such as an observational, translational, or epidemiologic study) or (2) a clinical trial, as long as it fits the exploratory and developmental nature of an R21.
What does "pilot and feasibility" mean in the context of this grant?
Based on the description provided, "pilot and feasibility" work is intended to answer early, practical questions such as whether a concept is workable, safe, recruitable, and measurable, and whether an approach (diagnostic or therapeutic) shows enough signal to justify a larger study.
What research area must applications focus on?
Projects must focus on urologic disorders, with an emphasis on important clinical and translational questions that could have meaningful clinical and public health impact.
What is the expected role of an R21 award in this program?
The R21 is positioned as a stepping stone or bridge between an idea with preliminary rationale and a later-stage, well-powered clinical study. NIH anticipates some awards will lead to larger follow-on studies, such as full-scale epidemiological investigations, diagnostic strategy validation, or randomized clinical trials for prevention, diagnosis, or treatment.
What is the maximum award amount (award ceiling) listed?
The award ceiling listed in the provided information is $200,000.
What is the Assistance Listing (CFDA) number for this program?
The Assistance Listing/CFDA number provided is 93.847.
What type of grant program is this described as?
It is described as a discretionary grant program using the NIH R21 mechanism.
Who is eligible to apply (in general terms)?
Eligibility is described as broad and includes many types of organizations, such as government entities, higher education institutions, nonprofit organizations, for-profit organizations (other than small businesses), and small businesses. The opportunity also calls out a variety of institution types and indicates foreign (non-U.S.) organizations are eligible.
Which U.S. government entities are eligible domestic applicants?
Eligible domestic applicants include state governments, county governments, city or township governments, and special district governments.
Are higher education institutions eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and independent school districts.
Are tribal governments and tribal organizations eligible?
Yes. The FOA includes federally recognized Native American tribal governments and Native American tribal organizations other than federally recognized tribal governments. It also references certain tribal governments that are not federally recognized as eligible.
Are nonprofits eligible? Does 501(c)(3) status matter?
Nonprofits are listed as eligible with or without 501(c)(3) status, as long as they are not institutions of higher education (as stated in the provided eligibility description).
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are included among eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. The announcement explicitly highlights faith-based or community-based organizations as eligible applicant types.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly highlighted as eligible.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The opportunity notes that non-domestic (non-U.S.) entities (foreign organizations) are listed as eligible, which may support international collaborations or work involving relevant populations or expertise outside the United States.
Does the FOA mention eligibility for specific institution categories like HBCUs or HSIs?
Yes. It explicitly highlights categories including Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and serving institutions such as Alaska Native and Native Hawaiian Serving Institutions and Asian American Native American Pacific Islander Serving Institutions (AANAPISI).
Does the FOA indicate whether it is current or from a past cycle?
The provided record shows an original closing date of April 4, 2018 and a creation date of November 15, 2017, indicating this posting reflects a specific historical application cycle. The description suggests that interested applicants would typically look for a current reissue, renewal, or related NIH FOA in the same program area and mechanism.
What is the broad activity/category area for this opportunity?
The source data lists the broad activity category as health.
What kinds of outcomes is NIH trying to enable through these pilot projects?
NIH is aiming to support projects that generate early evidence reviewers look for and help justify larger, definitive clinical studies that could ultimately improve prevention strategies, diagnostic approaches, or treatments in urologic health.
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Previous opportunity: Neuroscience Research on Drug Abuse (R21 Clinical Trial Optional)
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 18 101) also looked into and applied for these:
| Funding Opportunity |
|---|
| Small Grants for New Investigators to Promote Diversity in Health-Related Research (R21 Clinical Trial Optional) Apply for PAR 18 102 Funding Number: PAR 18 102 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $125,000 |
| Limited Competition: Small Grant Program for NIDDK K01/K08/K23 Recipients (R03 Clinical Trial Optional) Apply for PAR 18 103 Funding Number: PAR 18 103 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $50,000 |
| Addressing Health Disparities in NIDDK Diseases (R01 - Clinical Trial Not Allowed) Apply for PA 18 412 Funding Number: PA 18 412 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Ancillary Studies to Identify Behavioral and/or Psychological Phenotypes Contributing to Obesity (R01 Clinical Trial Optional) Apply for PAR 18 105 Funding Number: PAR 18 105 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R18 Clinical Trial Required) Apply for PAR 18 106 Funding Number: PAR 18 106 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Planning Grants for Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R34 Clinical Trial Required) Apply for PAR 18 107 Funding Number: PAR 18 107 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $150,000 |
| Elucidating HIV and HIV-treatment Associated Metabolic/Endocrine Dysfunction (R01 Clinical Trial Optional) Apply for RFA DK 17 036 Funding Number: RFA DK 17 036 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Pilot and Feasibility Therapeutic Clinical Trials in Diabetes, and Endocrine and Metabolic Diseases (R21- Clinical Trial Required) Apply for PA 18 405 Funding Number: PA 18 405 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| NIDDK Exploratory Clinical Trials for Small Business (R44 Clinical Trial Required) Apply for PAR 18 108 Funding Number: PAR 18 108 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional) Apply for PAR 18 423 Funding Number: PAR 18 423 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $225,000 |
| NIDDK Multi-Center Clinical Trial Cooperative Agreement (U01 Clinical Trial Required) Apply for PAR 18 415 Funding Number: PAR 18 415 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Innovative Research in HIV in Kidney, Urology, and Hematology (R01 Clinical Trial Optional) Apply for RFA DK 17 037 Funding Number: RFA DK 17 037 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| NIDDK Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed) Apply for PAR 18 414 Funding Number: PAR 18 414 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Mentored Research Scientist Development Award (K01-Clinical Trial Required) Apply for PAR 18 418 Funding Number: PAR 18 418 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Mentored Research Scientist Development Award (K01-No Independent Clinical Trials) Apply for PAR 18 419 Funding Number: PAR 18 419 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional) Apply for PAR 18 111 Funding Number: PAR 18 111 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Academic Research Enhancement Award in Diseases within the Mission of NIDDK (R15 - Clinical Trial Required) Apply for PA 18 495 Funding Number: PA 18 495 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Microphysiological Systems (MPS) for Modeling Diabetes (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA DK 17 035 Funding Number: RFA DK 17 035 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Ancillary Studies to the NIDDK Inflammatory Bowel Disease Genetics Consortium (R21 - Clinical Trial Optional) Apply for RFA DK 17 018 Funding Number: RFA DK 17 018 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $150,000 |
| Ancillary Studies to the NIDDK Inflammatory Bowel Disease Genetics Consortium (R01- Clinical Trial Optional) Apply for RFA DK 17 017 Funding Number: RFA DK 17 017 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
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