Scaling-up and Maintaining Evidence-based Interventions to Maximize Impact on Cancer (SUMMIT) - Tobacco Use Treatment for Cancer Survivors (UG3/UH3 Clinical Trial Required) | RFA CA 25 010

Opportunity Information: Apply for RFA CA 25 010

The National Institutes of Health is soliciting cooperative agreement applications under the SUMMIT initiative for research that improves how evidence-based tobacco use treatment (TUT) is scaled up and maintained for people who have survived cancer. The focus is not simply on proving that cessation treatments work, but on testing practical, real-world implementation strategies that help cancer programs and health systems deliver TUT consistently across many care settings, and keep those services operating over time. A central priority is equity: proposals are expected to address cancer survivor groups that experience health inequities and to design approaches that work in diverse clinical environments rather than only in highly resourced specialty centers.

This opportunity uses the UG3/UH3 phased cooperative agreement model and requires a clinical trial. In practice, that means projects are expected to begin with a time-limited planning, preparation, and feasibility phase (UG3) and then transition to a larger-scale implementation trial phase (UH3) if predefined milestones are met. The trial element is aimed at rigorously evaluating implementation strategies, such as methods for integrating cessation services into oncology workflows, improving referral and follow-up processes, strengthening clinician and staff behavior change supports, optimizing electronic health record prompts and care pathways, expanding access to counseling and pharmacotherapy, and ensuring that delivery models remain effective when rolled out broadly. Because this is an NIH cooperative agreement, awardees should expect substantial programmatic involvement from NIH staff compared with a standard research grant, often including coordination around milestones, progress assessment, and cross-project learning consistent with the SUMMIT emphasis on real-world impact.

The funded research projects are expected to test how to equitably and effectively expand TUT delivery to large numbers of cancer survivors across a wide variety of care delivery settings. That includes attention to sustainment: how TUT services continue after initial rollout, how they are supported through staffing, financing, leadership, policy, training, and workflow integration, and how they adapt to changing clinic conditions without losing effectiveness. Applications should therefore be oriented toward implementation science outcomes (for example, reach, adoption, fidelity, cost, sustainability, and equity-related measures) in addition to patient-level outcomes such as treatment engagement and cessation.

Eligibility is broad and includes many U.S.-based organization types: state, county, and city governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and other eligible entities. The NOFO also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, foreign organizations are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed, reinforcing that the work must be conducted within eligible domestic organizational structures.

Key administrative details in the source information include the funding opportunity title, “Scaling-up and Maintaining Evidence-based Interventions to Maximize Impact on Cancer (SUMMIT) - Tobacco Use Treatment for Cancer Survivors (UG3/UH3 Clinical Trial Required),” and the funding opportunity number RFA-CA-25-010. The funding instrument is a cooperative agreement, and the activity area aligns with education and health under CFDA 93.399. The original application due date listed is 2024-12-06, and the posting creation date is 2024-10-02. The award ceiling and expected number of awards are not specified in the provided excerpt, so applicants would need to consult the full NOFO for budget limits, project period parameters, milestone requirements for the UG3-to-UH3 transition, and any additional review criteria or program expectations.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Scaling-up and Maintaining Evidence-based Interventions to Maximize Impact on Cancer (SUMMIT) - Tobacco Use Treatment for Cancer Survivors (UG3/UH3 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.399.
• This funding opportunity was created on 2024-10-02.
• Applicants must submit their applications by 2024-12-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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