Opportunity Information: Apply for RFA MD 24 007
Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42 - Clinical Trial Optional) is a National Institutes of Health (NIH) funding opportunity that supports U.S. small businesses developing technologies that can be commercialized to improve minority health and reduce, and ultimately eliminate, health disparities. It is issued as an STTR program solicitation, which means projects are expected to involve a formal collaboration between a small business concern and a U.S. research institution, with the work structured to move an innovation toward a market-ready product, process, or service rather than stopping at early academic proof-of-concept.
The central goal is practical technology development aimed at populations that NIH identifies as experiencing health disparities. Proposed solutions should be designed with real-world uptake in mind, specifically emphasizing that technologies should be effective, affordable, and culturally acceptable. In practice, this points to products or services that can work in underserved settings, are feasible for the organizations and communities expected to use them, and are informed by the cultural, linguistic, and contextual needs of the people most affected by the disparity being targeted.
This opportunity uses the R41/R42 mechanism, which corresponds to the two-stage STTR structure. Phase I (R41) generally supports early feasibility and prototype development, while Phase II (R42) supports more advanced research and development to further mature the technology and position it for commercialization. The notice states "Clinical Trial Optional," meaning applicants may propose clinical trials if they are appropriate for the stage of development and the technology, but a clinical trial is not required for all projects. This allows both preclinical and clinically oriented technologies, as long as the development plan is consistent with commercialization and measurable impact on minority health and health disparities.
Eligibility is limited to eligible United States small business concerns. Foreign organizations are explicitly not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible to apply under this announcement. However, "foreign components" as defined in the NIH Grants Policy Statement may be allowed in some cases, which typically refers to limited, well-justified parts of the project being conducted outside the U.S. under NIH rules and prior approval expectations, rather than the project being led or primarily performed by a non-U.S. entity.
Administratively, the program is categorized as a discretionary grant opportunity in the health and education activity area, offered by the NIH. The funding opportunity number is RFA-MD-24-007, and it is associated with CFDA/Assistance Listing numbers 93.121, 93.286, 93.307, 93.350, and 93.361. The opportunity was created on 2024-03-08, and the listed application due date (original closing date) is 2026-12-09. The public summary does not specify an award ceiling or the expected number of awards, so applicants would typically rely on the full NOFO and NIH budget guidance for details on appropriate budgets, project periods, and competitiveness.
Overall, this NOFO is best understood as an applied, commercialization-oriented NIH STTR program focused on developing technologies that can tangibly improve health outcomes for populations experiencing disparities. Competitive projects are likely to be those that clearly define the disparity being addressed, demonstrate a credible technical development path, show how the solution will be affordable and culturally acceptable in the target settings, and present a realistic commercialization strategy that would enable sustained impact beyond the grant period.Apply for RFA MD 24 007
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42- Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.286, 93.307, 93.350, 93.361.
- This funding opportunity was created on 2024-03-08.
- Applicants must submit their applications by 2026-12-09. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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| Funding Opportunity |
|---|
| Research on the Neuro-Immune Axis in the Context of HIV and Substance Use (R21 Clinical Trial Not Allowed) Apply for RFA DA 25 005 Funding Number: RFA DA 25 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Research on the Neuro-Immune Axis in the context of HIV and Substance Use (R01 Clinical Trial Not Allowed) Apply for RFA DA 25 004 Funding Number: RFA DA 25 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Specialized Programs of Research Excellence (SPOREs) in Cancer Health Disparities and Minority Health (CHD-MH) (U54 Clinical Trial Optional) Apply for RFA CA 24 020 Funding Number: RFA CA 24 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,600,000 |
| Education Activities for Responsible Analyses of Complex, Large-Scale Data (R25- Clinical Trial Not Allowed) Apply for RFA DA 25 039 Funding Number: RFA DA 25 039 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Using Neuromodulation to Characterize the Continuum of Pathophysiology Between Substance Use and Mental Health Disorders (R01 Clinical Trial Required) Apply for RFA DA 25 035 Funding Number: RFA DA 25 035 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional) Apply for PAR 24 110 Funding Number: PAR 24 110 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| The NCI Worta McCaskill-Stevens Career Development Award for Community Oncology and Prevention Research (K12 Clinical Trial Optional) Apply for PAR 24 153 Funding Number: PAR 24 153 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Small Business Transition Grant For Early Career Scientists (R41/R42 Clinical Trial Not Allowed) Apply for RFA CA 24 023 Funding Number: RFA CA 24 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional) Apply for RFA CA 24 022 Funding Number: RFA CA 24 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Required) Apply for PA 24 178 Funding Number: PA 24 178 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Not Allowed) Apply for PA 24 179 Funding Number: PA 24 179 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Understanding the Intersection of Social Inequities to Optimize Health and Reduce Health Disparities: The Axes Initiative (R01 Clinical Trial Optional) Apply for RFA NR 24 006 Funding Number: RFA NR 24 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Independent Scientist Award (Parent K02 Independent Basic Experimental Studies with Humans Required) Apply for PA 24 180 Funding Number: PA 24 180 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional) Apply for PAR 24 207 Funding Number: PAR 24 207 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Establishing a Center for the Advancement of Substance Use Disorder (SUD) Pharmacotherapeutics (U54 Clinical Trials Not Allowed) Apply for RFA DA 25 056 Funding Number: RFA DA 25 056 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,900,000 |
| HEAL Initiative: JCOIN Phase II Clinical Research Hubs (UM1 Clinical Trial Required) Apply for RFA DA 25 025 Funding Number: RFA DA 25 025 Agency: National Institutes of Health Category: Education, Health Funding Amount: $5,000,000 |
| HEAL Initiative: JCOIN Phase II Economic Research Resource Center (U24 Clinical Trial Optional) Apply for RFA DA 25 061 Funding Number: RFA DA 25 061 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: JCOIN Phase II Community Engaged Research Resource Center (U24 Clinical Trial Optional) Apply for RFA DA 25 026 Funding Number: RFA DA 25 026 Agency: National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| HEAL Initiative: JCOIN Phase II Innovation Hubs (R01 Clinical Trial Optional) Apply for RFA DA 25 062 Funding Number: RFA DA 25 062 Agency: National Institutes of Health Category: Education, Health Funding Amount: $2,250,000 |
| Addressing Barriers to Healthcare Transitions for Survivors of Childhood and Adolescent Cancers (R01 Clinical Trial Optional) Apply for RFA CA 24 027 Funding Number: RFA CA 24 027 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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